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KMID : 0829320140170020058
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Korean Journal of Clinical Microbiology
2014 Volume.17 No. 2 p.58 ~ p.64
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Factors Influencing the False Positive Signals of Continuous Monitoring Blood Culture System
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Uh Young
Jang In-Ho
Park Soon-Deok
Kim Kab-Seung
Seo Dong-Min
Yoon Kap-Jun
Choi Hee-Kyoung
Kim Young-Keun
Kim Hyo-Youl
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Abstract
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Background: The false positive signals of a continuous monitoring blood culture system (CMBCS) increase the reporting time and laboratory cost. This study aimed to determine the highly relevant variables that discriminate false positive signals from true positive signals in a CMBCS.
Methods: Among 184,363 blood culture sets (aerobicand anaerobic), the signal-positive samples according to a BACTEC FX system (Plus Aerobic/F, BDA; PlusAnaerobic/F, BDN) and BacT/Alert 3D system (Standard Aerobic, BSA; Standard Anaerobic, BSN) between April 2010 and November 2013 were classified into two groups: false positive or true positive signals. The data of 15 parameters between the two groups were then statistically compared.
Results: Among total blood cultures, the positive rates of CMBCS signals according to BDA, BDN,BSA, and BSN were 4.9%, 2.8%, 3.8%, and 3.2%,respectively. The false positive rates of CMBCS signalsa ccording to BDA, BDN, BSA, and BSN were0.6%, 0.1%, 0.1%, and 0.1%, respectively. The blood volume, detection time, time interval between admission and test, C-reactive protein concentration, leukocyte count, delta neutrophil index, and mean peroxidase index showed statistically significant differences between the two groups.
Conclusion: There were no variables with diagnostic sensitivity and specificity for discriminating the twogroups. Therefore, analysis of bacterial growth curves produced by CMBCS is needed for early and effective detection of false positive signals.
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KEYWORD
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Blood, Culture, False positive, Monitoring, Signal
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